L-Type Ca2+ Channel Cavb Subunits Associate with and Differentially Regulate the Cardiac Cav3.2 T-Type Ca2+ Channel Currents

Low voltage activated T-type calcium channels (TTCC) play a pivotal role in the developing heart. Although the TTCC isoforms, Cav3.1 and Cav3.2, underlie cardiac TTCC current (ICa,T) and are expressed in atrial and ventricular myocytes during development, their expression and roles recede in the adult heart. However, previous studies have demonstrated the re-expression of ICa,T in pathological cardiac hypertrophy, suggesting that TTCCs...