Prolactin and depression: two models

Data from a variety of studies attempting to delineate a causative role for prolactin, or dopamine depletion with resultant hyperprolactinemia, in depression have suggested a possible role for an amine depletion model, but the evidence is contradictory. One single model does not explain prolactin levels after antidepressant therapy, blunted prolactin response to dynamic challenge, normal baseline prolactin values and the antidepressant effects...