Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides
Abstract
Human endothelial cells (EC) express Toll-like receptor 4 (TLR4), a receptor for lipopolysaccharides (LPS), but little or no TLR2, a lipopeptide receptor. The aim of this study was to investigate to what extent inflammatory stimuli modify the expression by EC of TLR4 and TLR2, of the TLR2 co-receptors TLR1 and TLR6 and of the TLR2-accessory proteins CD14 and CD36. Stimulation of umbilical vein derived EC with TNF-alpha, LPS or IL-1beta for 24h...
Paper Details
Title
Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides
Published Date
Nov 1, 2008
Journal
Volume
46
Issue
1
Pages
145 - 157
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