Pharmacokinetics and Pharmacodynamics of a Sustained-Release Dexamethasone Intravitreal Implant
Volume: 52, Issue: 1, Pages: 80 - 80
Published: Jan 5, 2011
Abstract
Purpose.: To determine the pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone (DEX) intravitreal implant (Ozurdex; Allergan, Inc.). Methods.: Thirty-four male monkeys (Macaca fascicularis) received bilateral 0.7-mg DEX implants. Blood, vitreous humor, and retina samples were collected at predetermined intervals up to 270 days after administration. DEX was quantified by liquid chromatography–tandem mass spectrometry, and...
Paper Details
Title
Pharmacokinetics and Pharmacodynamics of a Sustained-Release Dexamethasone Intravitreal Implant
Published Date
Jan 5, 2011
Volume
52
Issue
1
Pages
80 - 80
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