Hepcidin production in response to iron is controlled by monocyte-derived humoral factors
Abstract
Hepcidin, which is mainly produced by the liver, is the key regulator in iron homeostasis. Hepcidin expression is up-regulated by iron loading in vivo, but the mechanism underlying this process is not completely understood. In the present study, we investigated the mechanism, following the hypothesis that hepcidin production in response to iron loading is regulated by extra-hepatic iron sensors. We measured serum hepcidin concentrations and iron...
Paper Details
Title
Hepcidin production in response to iron is controlled by monocyte-derived humoral factors
Published Date
Dec 1, 2013
Volume
99
Issue
1
Pages
12 - 20
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