Enantioselective pharmacodynamics of propranolol in HUVEC cells: A study using chiral 2D gel electrophoresis and mass spectrometry

Propranolol (PRO), a nonselective β-adrenergic receptor (β-AR) antagonist, has two enantiomers, R(+)-PRO and S(-)-PRO, which have diverse biological effects. For example, S(-)-PRO blocks the β-receptor ~100 times more strongly than R(+)-PRO. However, the signaling pathway that causes this difference remains unclear. This pathway may affect the expression of numerous proteins, some of which play key roles during the drug action process....