p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species
Abstract
p38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress. The most abundant family member is p38α, which helps to couple cell proliferation and growth in response to certain damaging stimuli. In fact, increased proliferation and impaired differentiation are hallmarks of p38α-deficient cells. It...
Paper Details
Title
p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species
Published Date
Oct 4, 2013
Journal
Volume
47
Issue
11
Pages
905 - 916
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