Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments
Abstract
Toll-like receptor (TLR)-2/TLR1 heterodimers recognize bacterial lipopeptides and initiate the production of inflammatory mediators. Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors and co-receptors function, are still being discovered.Using shRNA, blocking antibodies, and fluorescent microscopy, we show that U937 macrophage responses to the TLR2/1 ligand, Pam(3)CSK(4), are dependent upon an...
Paper Details
Title
Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments
Published Date
Sep 22, 2010
Journal
Volume
5
Issue
9
Pages
e12871 - e12871
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