Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice

Volume: 46, Issue: 5, Pages: 433 - 439
Published: May 1, 2014
Abstract
Background The role of Kupffer cell interleukin (IL)-1 in non-alcoholic steatohepatitis development remains unclear. Aims To evaluate the role of Kupffer cell IL-1α, IL-1β or IL-1 receptor type-1 (IL-1R1) in steatohepatitis. Methods C57BL/6 mice were irradiated and transplanted with bone marrow-derived cells from WT, IL-1α−/−, IL-1β−/− or IL-1R1−/− mice combined with Kupffer cell ablation with Gadolinium Chloride, and fed atherogenic diet....
Paper Details
Title
Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice
Published Date
May 1, 2014
Volume
46
Issue
5
Pages
433 - 439
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