Isoliquiritigenin, One of the Antispasmodic Principles of Glycyrrhiza Ularensis Roots, Acts in the Lower Part of Intestine

Glycyrrhizae Radix is used to treat abdominal pain as a component of Shakuyakukanzoto (Shaoyao-Gancao-tang), a traditional Chinese medicine formulation. Previously, we have reported the isolation of glycycoumarin as a potent antispasmodic with an IC50 value of 2.93±0.94 μM for carbamylcholine (CCh)-induced contraction of mouse jejunum from an aqueous extract of Glycyrrhizae Radix (licorice), and clarified that its mechanism of action involves...