Ketamine Disrupts Theta Modulation of Gamma in a Computer Model of Hippocampus
Abstract
Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multicompartment neurons [pyramidal, basket, and oriens-lacunosum moleculare (OLM) cells] generated theta and gamma oscillations from intrinsic network...
Paper Details
Title
Ketamine Disrupts Theta Modulation of Gamma in a Computer Model of Hippocampus
Published Date
Aug 10, 2011
Journal
Volume
31
Issue
32
Pages
11733 - 11743
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