Structural and functional analysis of the Entamoeba histolytica EhrabB gene promoter

The Entamoeba histolytica EhrabB gene encodes for a Rab GTPase involved in phagocytosis. It is located at a virulence locus where the Ehcp112 gene is in the complementary strand at 332 bp of EhrabB start codon, suggesting a finely regulated transcription of both genes. However, the transcription regulation in this parasite is poorly understood. To initiate the knowledge of EhrabB gene expression regulation, here we studied the structural...