The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs

In this study we investigated the ability of aerosolized substance P to induce either cough or bronchoconstriction in guinea-pigs. We have also examined whether pre-treatment, by the inhaled route, of animals with a combination of the neutral endopeptidase inhibitor, phosphoramidon (10−3 M), and the diaminopeptidase IV inhibitor, diprotin A (10−3 M), enhances the airway response to substance P. Moreover, we also assessed whether aerosol...