Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium
Abstract
In vitro models of normal mammary epithelium have correlated increased extracellular matrix (ECM) stiffness with malignant phenotypes. However, the role of increased stiffness in this transformation remains unclear because of difficulties in controlling ECM stiffness, composition and architecture independently. Here we demonstrate that interpenetrating networks of reconstituted basement membrane matrix and alginate can be used to modulate ECM...
Paper Details
Title
Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium
Published Date
Jun 15, 2014
Journal
Volume
13
Issue
10
Pages
970 - 978
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