Toxicogenomic investigation on rat testicular toxicity elicited by 1,3-dinitrobenzene

Volume: 290, Issue: 2-3, Pages: 169 - 177
Published: Dec 1, 2011
Abstract
Rats were treated with a single oral dose of 10, 25 and 50mg/kg of 1,3-dinitrobenzene (DNB), and the testis was subjected to a GeneChip microarray analysis. A total of 186 and 304 gene probe sets were up- and down-regulated, respectively, by the DNB treatment, where spermatocyte death and Sertoli cell vacuolation in testis and increased debris of spermatogenic cell in epididymis were noted. The expression profile for four sets of genes were...
Paper Details
Title
Toxicogenomic investigation on rat testicular toxicity elicited by 1,3-dinitrobenzene
Published Date
Dec 1, 2011
Journal
Volume
290
Issue
2-3
Pages
169 - 177
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