Efficacy evaluation of physostigmine and anticholinergic adjuncts as a pretreatment for nerve agent intoxication
Abstract
Pretreatment of nonhuman primates with physostigmine (Phy) and scopolamine or physostigmine and trihexyphenidyl 25 min before exposure to 2 LD50 soman im resulted in complete survival without convulsions or loss of consciousness. When identically pretreated animals were challenged with 5 LD50s of soman followed by atropine and 2-PAM therapy 1 min later, all animals experienced a loss of consciousness for approximately 10 min followed by...
Paper Details
Title
Efficacy evaluation of physostigmine and anticholinergic adjuncts as a pretreatment for nerve agent intoxication
Published Date
Nov 1, 1991
Volume
17
Issue
4
Pages
782 - 789
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