The Single-Molecule Mechanics of the Latent TGF-β1 Complex

Volume: 21, Issue: 24, Pages: 2046 - 2054
Published: Dec 20, 2011
Abstract
Summary null Background null TGF-β1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-β1 binds to the latent TGF-β1-binding protein-1 (LTBP-1), which is part of the extracellular matrix (ECM). Transmission of cell force via integrins is one major mechanism to activate latent TGF-β1 from ECM stores. Latent TGF-β1 mechanical activation...
Paper Details
Title
The Single-Molecule Mechanics of the Latent TGF-β1 Complex
Published Date
Dec 20, 2011
Volume
21
Issue
24
Pages
2046 - 2054
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