Long-Term Results of the M. D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer

Purpose To report the long-term results of a randomized radiotherapy dose escalation trial for prostate cancer. Methods and Materials From 1993 to 1998, a total of 301 patients with stage T1b to T3 prostate cancer were accrued to a randomized external beam dose escalation trial using 70 Gy versus 78 Gy. The median follow-up is now 8.7 years. Kaplan-Meier analysis was used to compute rates of prostate-specific antigen (PSA) failure (nadir + 2),...