The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation

Volume: 285, Issue: 14, Pages: 10434 - 10445
Published: Apr 2, 2010
Abstract
Fibrotic tissue is characterized by an overabundance of myofibroblasts. Thus, understanding the factors that induce myofibroblast differentiation is paramount to preventing fibrotic healing. Previous studies have shown that mechanical stress derived from the integrin-mediated interaction between extracellular matrix and the cytoskeleton promotes myofibroblast differentiation. Integrin α11β1 is a collagen receptor on fibroblasts. To determine...
Paper Details
Title
The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation
Published Date
Apr 2, 2010
Volume
285
Issue
14
Pages
10434 - 10445
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