A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK

Volume: 20, Issue: 19, Pages: 5421 - 5430
Published: Oct 1, 2001
Abstract
In cultured mammalian cells, the p38 mitogen-activated protein kinase (MAPK) pathway is activated in response to a variety of environmental stresses. How ever, there is little evidence from in vivo studies to demonstrate a role for this pathway in the stress response. We identified a Drosophila MAPK kinase kinase (MAPKKK), D-MEKK1, which can activate p38 MAPK. D-MEKK1 is structurally similar to the mammalian MEKK4/MTK1 MAPKKK. D-MEKK1 kinase...
Paper Details
Title
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK
Published Date
Oct 1, 2001
Volume
20
Issue
19
Pages
5421 - 5430
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