Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
Abstract
Disappointing results from most late-stage clinical trials of cancer therapeutics indicate a need for improved and more-predictive animal tumor models. This insufficiency of models, combined with the advent of a class of drugs that target the tumor microenvironment rather than the tumor cell, presents new challenges for designing and interpreting preclinical efficacy studies. A comparison of the clinical efficacy of anti-angiogenic drugs with...
Paper Details
Title
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
Published Date
Jul 1, 2012
Journal
Volume
30
Issue
7
Pages
648 - 657
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Notes
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