ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner
Abstract
Autophagy is a normal degradative pathway that involves the sequestration of cytoplasmic components and organelles in a vacuole called autophagosome. SNAREs proteins are key molecules of the vesicle fusion machinery. Our results indicate that in a mammalian tumor cell line a subset of VAMP7 (V-SNARE)-positive vacuoles colocalize with LC3 at the cell periphery (focal adhesions) upon starvation. The re-distribution of VAMP7 positive structures is...
Paper Details
Title
ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner
Published Date
Dec 1, 2012
Journal
Volume
8
Issue
12
Pages
1741 - 1756
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Notes
History