Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe
Abstract
Human serum transferrin (hTF) binds Fe(III) tightly but reversibly, and delivers it to cells via a receptor-mediated endocytosis process. The metal-binding and release result in significant conformational changes of the protein. Here, we report the crystal structures of diferric-hTF (Fe(N)Fe(C)-hTF) and bismuth-bound hTF (Bi(N)Fe(C)-hTF) at 2.8 and 2.4 Å resolutions respectively. Notably, the N-lobes of both structures exhibit unique...
Paper Details
Title
Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe
Published Date
Dec 19, 2012
Journal
Volume
2
Issue
1
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