HB-EGF promotes angiogenesis in endothelial cells via PI3-kinase and MAPK signaling pathways

Volume: 25, Issue: 4, Pages: 253 - 263
Published: Aug 1, 2007
Abstract
Objective: Heparin-binding EGF-like growth factor (HB-EGF) belongs to the epidermal growth factor (EGF) superfamily of ligands. It has been implicated as a regulator of angiogenesis. However, the mechanisms by which HB-EGF promotes angiogenesis are unknown. The goal of the present study was to define the pathways by which HB-EGF stimulates angiogenesis in endothelial cells.Methods: To characterize the angiogenic activity of HB-EGF, we treated...
Paper Details
Title
HB-EGF promotes angiogenesis in endothelial cells via PI3-kinase and MAPK signaling pathways
Published Date
Aug 1, 2007
Volume
25
Issue
4
Pages
253 - 263
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