Effect of Needle Revision of Failed Filtering Blebs with Different Concentrations of Mitomycin C

Published on Jun 1, 2008in Journal of The Korean Ophthalmological Society
· DOI :10.3341/JKOS.2008.49.6.951
Kyeong Jin Woo3
Estimated H-index: 3
(CBNU: Chungbuk National University),
Sungmin Hyung4
Estimated H-index: 4
(CBNU: Chungbuk National University)
Purpose: To investigate the efficacy and the risk factors for failure and complications of mitomycin C (MMC)-augmented needle revision (NR) of failed filtering blebs. Methods: Thirty eyes whose intraocular pressure (IOP) did not decrease after the cutting of scleral flap sutures were recruited. NR was performed with a 26-gauge needle under a slit-lamp. Immediately following NR, all eyes received a subconjunctival injection of 0.1 ml of 0.02 mg/ml (group A) or 0.1 mg/ml (group B) MMC at the adjacent conjunctiva. The mean follow-up period after the last needle revision was 13.2±4.2 months. Results: The mean IOP decreased from 25.7±10.6 mmHg before surgery to 13.7±2.5 mmHg at the last follow-up in group A and from 24.1±6.8 mmHg to 17.7±8.6 mmHg in group B (group A: p=0.001, group B: p=0.065). Subconjunctival hemorrhage, hyphema, and a shallow anterior chamber appeared in most cases. However, choridal detachment and avascular changes of the conjunctiva were observed in group B. Conclusions: IOP decreased in both groups A and B, but severe complications appeared only in group B. NR followed by a subconjunctival injection of 0.02 rather than 0.1 mg/ml is a safe and effective method. J Korean Ophthalmol Soc 49(6):951-957, 2008
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