A recipe for targeted therapy in prostate cancer

In their Review, Marignol and colleagues discuss the comprehensive knowledge of the biology of prostate cancer, which is deeply associated with hypoxia and notch signalling (Marignol, L., Rivera-Figueroa, K., Lynch, T. & Hollywood, D. Hypoxia, notch signalling, and prostate cancer. Nat. Rev. Urol. 10, 405–413; 2013).1 On this topic, an additional three issues related to targeted therapy should be discussed based on recent evidence: the role of...