Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives
Abstract
30 novel compounds have been synthesized from 25-hydroxyprotopanaxadiol (25-OH–PPD) and their in vitro anti-tumor activities were tested on three cancer cell lines and one normal cell line (IOSE144) by standard MTT assay. The results showed that compound 27 exhibited the best anti-tumor activity in the in vitro assays. Compounds 1, 2, 16, 17, 18, 27, 28 and 29 have better anti-tumor activities against MCF-7 and A549 cancer cell lines than...
Paper Details
Title
Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives
Published Date
Sep 1, 2012
Volume
55
Pages
137 - 145
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