Reduction of Apoptosis in Ischemic Retinas of Two Mouse Models Using Hyperbaric Oxygen Treatment

Purpose.: To investigate the effect of hyperbaric oxygen (HBO) chamber treatment in mouse models of retinal ischemia. Methods.: Unilateral central retinal artery occlusion (CRAO) or optic nerve crush (ONC) was induced in 50 mice each, of which 30 were treated with 100% oxygen at 2 atm for 90 minutes immediately after injury and then daily for up to 14 days. Mice were euthanatized on days 1, 3, and 21 for histologic analysis, apoptosis assay, and...