Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3
Abstract
Vascular endothelial growth factor (VEGF) is the most potent stimulatory factor of angiogenesis. Its expression is induced by reactive oxygen species (ROS) in hypoxic conditions and by insulin in normoxic cells. Both ROS and insulin can activate mitogen-activated protein kinases (MAPKs) and induce the transcriptional factor Sp1, components that are essential for VEGF gene expression. The aim of this study was to investigate the role of ROS...
Paper Details
Title
Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3
Published Date
Oct 1, 2006
Journal
Volume
312
Issue
17
Pages
3413 - 3424
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