Defective Apoptotic Cell Phagocytosis Attenuates Prostaglandin E₂and 15-Hydroxyeicosatetraenoic Acid in Severe Asthma Alveolar Macrophages

Clearance of apoptotic cells is crucial to the resolution of inflammation and development of fibrosis, but the process is not well understood in normal or diseased human lungs.To determine phagocytosis of apoptotic cells by primary human alveolar macrophages and whether defects in uptake of apoptotic cells are associated with decreases in antiinflammatory/antifibrotic mediators.Human bronchoalveolar lavage macrophages (AMphis) from normal...