Miller Fisher anti-GQ1b antibodies: ?-Latrotoxin-like effects on motor end plates
Abstract
In the Miller Fisher syndrome (MFS) variant of the Guillain-Barré syndrome, weakness is restricted to extraocular muscles and occasionally other craniobulbar muscles. Most MFS patients have serum antibodies against ganglioside type GQ1b of which the pathophysiological relevance is unclear. We examined the in vitro effects of MFS sera, MFS IgG, and a human monoclonal anti-GQ1b IgM antibody on mouse neuromuscular junctions (NMJs). It was found...
Paper Details
Title
Miller Fisher anti-GQ1b antibodies: ?-Latrotoxin-like effects on motor end plates
Published Date
Feb 1, 1999
Journal
Volume
45
Issue
2
Pages
189 - 199
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