Persistent Homocysteine Metabolism Abnormality Accelerates Cardiovascular Disease in Hemodialyzed Patients—the Nishinomiya Study

Homocysteine (Hcy) is an intermediate in sulfur amino acid metabolism and may induce oxidative stress. Several studies have reported that elevated Hcy in end-stage renal failure may contribute to cardiovascular disease (CVD). The purpose of this study is to investigate whether the changes in Hcy levels correlate better with the CVD outcomes than baseline Hcy level.A total of 187 patients on dialysis participated in the present prospective...