Primary antibody response to keyhole limpet hemocyanin in rat as a model for immunotoxicity evaluation.

Volume: 197, Issue: 1, Pages: 23 - 35
Published: Apr 1, 2004
Abstract
To address current regulatory expectations on immunotoxicity testing of new chemicals, we describe an animal model that measures the primary antibody response to the T-cell dependent antigen, keyhole limpet hemocyanin (KLH). Single immunization with KLH by either footpad (300microg/rat) or intravenous (300microg/kg) route in Sprague Dawley rats resulted in increased germinal center formation in the spleen and a robust anti-KLH IgM...
Paper Details
Title
Primary antibody response to keyhole limpet hemocyanin in rat as a model for immunotoxicity evaluation.
Published Date
Apr 1, 2004
Journal
Volume
197
Issue
1
Pages
23 - 35
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.