Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α

Science56.90
Volume: 330, Issue: 6005, Pages: 827 - 830
Published: Nov 5, 2010
Abstract
The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal cells, suppresses immune control of tumor growth. A stromal cell type that was first identified in human cancers expresses fibroblast activation protein-α (FAP). We created a transgenic mouse in which FAP-expressing cells can be ablated. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas,...
Paper Details
Title
Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α
Published Date
Nov 5, 2010
Journal
Volume
330
Issue
6005
Pages
827 - 830
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