Blockade of platelet alpha2B-adrenergic receptors: A novel antiaggregant mechanism

Platelets play a vital role in hemostasis and thrombosis. Catecholamines have a profound effect on platelet aggregation and atherothrombosis but the exact mechanism involved is insufficiently understood. In this report, we demonstrate the existence and role of alpha2B-adrenergic receptors (α2B-ARs) in normal human platelets.Sixteen healthy individuals were recruited as donors of normal blood from which platelets were isolated. The presence of...