The current state of serum biomarkers of hepatotoxicity
Abstract
The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes and is considered to be a highly sensitive and fairly specific preclinical and clinical biomarker of hepatotoxicity. However, an increase in serum ALT activity level has also been associated with other organ toxicities, thus, indicating that the enzyme has specificity beyond liver in the absence of correlative histomorphologic alteration in liver. Thus,...
Paper Details
Title
The current state of serum biomarkers of hepatotoxicity
Published Date
Mar 1, 2008
Journal
Volume
245
Issue
3
Pages
194 - 205
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