Thiolated nanocarriers for oral delivery of hydrophilic macromolecular drugs
Abstract
It was the aim of this study to investigate the effect of unmodified as well as thiolated anionic poly(acrylic acid) (PAA) and cationic chitosan (CS) utilized in free-soluble form and as nanoparticulate system on the absorption of the hydrophilic compound FD4 across intestinal epithelial cell layer with and without a mucus layer. Modifications of these polymers were achieved by conjugation with cysteine to PAA (PAA-Cys) and thioglycolic acid to...
Paper Details
Title
Thiolated nanocarriers for oral delivery of hydrophilic macromolecular drugs
Published Date
Mar 1, 2015
Journal
Volume
117
Pages
577 - 584
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