GTP in the mitochondrial matrix plays a crucial role in organellar iron homoeostasis
Abstract
Mitochondria are the major site of cellular iron utilization for the synthesis of essential cofactors such as iron–sulfur clusters and haem. In the present study, we provide evidence that GTP in the mitochondrial matrix is involved in organellar iron homoeostasis. A mutant of yeast Saccharomyces cerevisiae lacking the mitochondrial GTP/GDP carrier protein (Ggc1p) exhibits decreased levels of matrix GTP and increased levels of matrix GDP [Vozza,...
Paper Details
Title
GTP in the mitochondrial matrix plays a crucial role in organellar iron homoeostasis
Published Date
Oct 27, 2006
Journal
Volume
400
Issue
1
Pages
163 - 168
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