The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration

Published on Jun 1, 2013in Journal of Gastroenterology6.132
· DOI :10.1007/S00535-012-0677-X
Yuri Fukui6
Estimated H-index: 6
(Kansai Medical University),
Kazushige Uchida30
Estimated H-index: 30
(Kansai Medical University)
+ 16 AuthorsKazuichi Okazaki85
Estimated H-index: 85
(Kansai Medical University)
Sources
Abstract
Background High serum immunoglobulin G4 (IgG4) levels and infiltration of IgG4-positive cells are characteristic of Type 1 autoimmune pancreatitis (AIP). We previously reported that increased regulatory T cells (Tregs) may regulate IgG4 production in AIP. Although an increased serum IgG4 concentration is observed in some patients with pancreatic ductal adenocarcinoma (PDA), clarification is still necessary. We have therefore studied the correlations between IgG4-positive cells and Tregs in patients with PDA.
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