Vascular proliferation and transforming growth factor-β expression in pre- and early stage of diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats
Abstract
The roles of transforming growth factor (TGF)-beta 1 in vascular proliferation, atherosclerosis, and plaque still remain controversial. TGF-beta 1 has been previously reported to inhibit the proliferation and migration of vascular smooth muscle cells and endothelial cells, in vitro. On the other hand, administration or transgenic overexpression of TGF-beta 1 enhances extracellular matrix synthesis and cellular hyperplasia of the intima and media...
Paper Details
Title
Vascular proliferation and transforming growth factor-β expression in pre- and early stage of diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats
Published Date
May 1, 2002
Journal
Volume
162
Issue
1
Pages
69 - 76
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