Transcript Scanning Reveals Novel and Extensive Splice Variations in Human L-type Voltage-gated Calcium Channel, Cav1.2 α1 Subunit

The L-type (Cav1.2) voltage-gated calcium channels play critical roles in membrane excitability, gene expression, and muscle contraction. The generation of splice variants by the alternative splicing of the poreforming Cav1.2 α1-subunit (α11.2) may thereby provide potent means to enrich functional diversity. To date, however, no comprehensive scan of α1 1.2 splice variation has been performed, particularly in the human context. Here we have...