Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments
Abstract
Addition chemistries are widely used in preparing biological conjugates, and in particular, maleimide-thiol adducts have been widely employed. Here, we show that the resulting succinimide thioether formed by the Michael-type addition of thiols to N-ethylmaleimide (NEM), generally accepted as stable, undergoes retro and exchange reactions in the presence of other thiol compounds at physiological pH and temperature, offering a novel strategy for...
Paper Details
Title
Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments
Published Date
Sep 26, 2011
Journal
Volume
22
Issue
10
Pages
1946 - 1953
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