Preparation, swelling characteristics and evaluation of hydrogels for stomach specific drug delivery

The development of pH sensitive, biocompatible and biodegradable hydrogels as novel drug delivery systems was carried out to achieve localized drug delivery. Poly[N-vinyl pyrrolidone-acrylic acid]-polyethylene glycol (Poly[NVP-AA]-PEG) interpolymer type systems were prepared by free radical polymerization. Azobisisobutyronitrile (AIBN) was used for initiating the polymerization and N,N″-methylene bisacrylamide was employed as a crosslinking...