Nordihydroguaiaretic acid activates hTRPA 1 and modulates behavioral responses to noxious cold in mice

Volume: 2, Issue: 6
Published: Sep 1, 2014
Abstract
Nordihydroguaiaretic acid (NDGA) is a major biologically active component of the creosote bush, Larrea tridentate, widely used in unregulated therapies. NDGA is a lipoxygenase inhibitor while a derivative, terameprocol, has been trialed as a chemotherapeutic agent. When investigating fatty acid activation of the human transient receptor potential cation channel subfamily A, member 1 (hTRPA1), we found that NDGA activated the channel. Here we...
Paper Details
Title
Nordihydroguaiaretic acid activates hTRPA 1 and modulates behavioral responses to noxious cold in mice
Published Date
Sep 1, 2014
Volume
2
Issue
6
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