Effect of dominant negative SNAP‐23 expression on platelet function

The protein SNAP-23 is part of the secretory pathway in platelets. It is, however, not entirely clear to what extent this protein contributes to the secretory function of platelets. Therefore, we overexpressed a dominant negative mutant with a novel technology that allows the creation of intact transgene-expressing platetets.Overexpression of a dominant negative SNAP-23 mutant that inhibited the binding of the native protein to the docking site...