Reconstitution and functional characterization of the unusual bi‐subunit type I DNA topoisomerase from Leishmania donovani
Abstract
Leishmania donovani topoisomerase I is an unusual bi-subunit enzyme. The activity of the enzyme has been detected when the genes of the individual subunits were co-expressed in yeast [J. Biol. Chem. 278 (2003) 3521]. Here, we report for the first time, the in vitro reconstitution of the two recombinant proteins, LdTOP1L and LdTOP1S, corresponding to the large and small subunits and localization of the active enzyme in both the nucleus and...
Paper Details
Title
Reconstitution and functional characterization of the unusual bi‐subunit type I DNA topoisomerase from Leishmania donovani
Published Date
Apr 9, 2004
Journal
Volume
565
Issue
1-3
Pages
81 - 88
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