Obesity and cancer—mechanisms underlying tumour progression and recurrence

Obesity is associated with an increased risk of certain cancers, such as breast and colon cancers and hepatocellular carcinoma. In this Review, the authors discuss the mechanisms that underlie the interplay between tumour cells and adipocyte-rich stromal tissues that drives the creation and maintenance of a unique microenvironment that favours tumour growth and metastasis. Over the past several years, the field of cancer research has directed...