Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Abstract
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional...
Paper Details
Title
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Published Date
Aug 12, 2012
Journal
Volume
44
Issue
9
Pages
981 - 990
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