Gene Therapy of Endothelial Nitric Oxide Synthase and Manganese Superoxide Dismutase Restores Delayed Wound Healing in Type 1 Diabetic Mice

Volume: 110, Issue: 16, Pages: 2484 - 2493
Published: Oct 19, 2004
Abstract
Background— Nitric oxide (NO) deficiency contributes to diabetic wound healing impairment. The present study tested the hypothesis that increased cutaneous superoxide (O2−) levels in type 1 diabetic mice cause NO deficiency and delayed wound healing. Methods and Results— Wound healing was markedly delayed in streptozotocin-induced type 1 diabetic mice compared with the normal controls. There were significantly reduced levels of endothelial NO...
Paper Details
Title
Gene Therapy of Endothelial Nitric Oxide Synthase and Manganese Superoxide Dismutase Restores Delayed Wound Healing in Type 1 Diabetic Mice
Published Date
Oct 19, 2004
Volume
110
Issue
16
Pages
2484 - 2493
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