Association of a Functional Polymorphism in the Clopidogrel Target Receptor Gene, P2Y12 , and the Risk for Ischemic Cerebrovascular Events in Patients With Peripheral Artery Disease

Background and Purpose— There is considerable variability in the antiplatelet effects of the thienopyridine agent “clopidogrel.” We tested for an association of gene sequence variations in P2Y12 and occurrence of neurological adverse events in patients with symptomatic peripheral artery disease (PAD) during clopidogrel treatment. Methods— We studied 137 patients undergoing antiplatelet therapy with clopidogrel and 336 patients with aspirin for...